Published in the Journal of biomechanics in 2015. The originial version is available from the original publisher or via the doi: dx.doi.org/10.1016/j.jbiomech.2014.11.025. A preprint version may be available in the NUI Galway Aran Repository. A list of papers citing this article can be found on Google Scholar. The abstract, citation, and some sample pages are shown below.

Sample pages We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces exerted by the cell and these show that the cell-cell tugging stress is a constant and independent of the cell-cell junction area. In the current study, we demonstrate that a material model which includes the underlying cellular processes of stress fibre contractility and adhesion formation can capture these results. The simulations explain the experimentally observed phenomena whereby the cell-cell junction forces increase with junction size but the tractions exerted by the cell on the micro-post array are independent of the junction size. Further simulations on different types of micro-post arrays and cell phenotypes are presented as a guide to future experiments.

Please cite this article as: Ronan, W., McMeeking, R. M., Chen, C. S., McGarry, J. P., & Deshpande, V. S. (2015). Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions. Journal of biomechanics, 48(3), 520-528.